The images of histological sections showed that the fibrosis process is more accentuated in animals that were treated with the HGPRT enzyme, as the eggs were more likely to be destroyed and the fibrous process was also accentuated, showing that HGPRT can positively interfere in the physiopathology process of schistosomiasis that severely affects the liver. Here, HPRT1 is linked to schistosomiasis.