It is feasible to see that the control group’s animals’ livers exhibit preserved tissue and without the presence of granulomas or eggs and, in the animals of the Sm, Sm + HGPRT, Sm + PNP and Sm + MIX groups, there is the formation of periovular granuloma, with mixed cellular infiltrate and fibrosis of the vessels. The gene discussed is HPRT1; the disease is Granuloma.