Subsequently, following an in-depth comparison of the Indian cohort (adult and children) and the African cohorts of children with CM based on the molecular, immunological, and neurological profiles aided by machine-learning models, it was demonstrated that the pathogenetic mechanisms of CM may have common brain swelling determinants, e.g., elevated levels of Endothelial protein C receptor (EPCR) binding var gene transcripts as well as higher levels of parasite biomass [23]. The gene discussed is PROCR; the disease is cutaneous mastocytosis.