In the substantia nigra, following overall differences in ANA levels (p = 0.003) (Figure 9) and the KYN/TRP ratio (p = 0.001) (Figure 10), we found that these levels were significantly lower in ALS compared to EOAD and FTD patients, although differences between ALS and FTD patients were no longer significant upon Bonferroni correction. The gene discussed is BTG3; the disease is frontotemporal dementia.