Since both disease entities affect different brain structures, we might expect to see more neuroinflammation and KP activity in BA22 and the hippocampus (frontotemporal structures) in FTD patients, whereas we could expect higher neuroinflammation levels in ALS compared to FTD patients in motor-associated areas such as the neostriatum, substantia nigra and BA6. Here, NPPA is linked to amyotrophic lateral sclerosis.