Although it is yet to be investigated whether DCPIB and ML67-33 can promote the clearance of p-α-syn aggregates in PD neurons (especially those from PD patients carrying the M393T TMEM175 variant), activation of TMEM175 to restore lysosomal function appears to be an attractive therapeutic approach of PD (Table 1) [47,90]. Here, TMEM175 is linked to Parkinson disease.