Compared with DOTA-(2P-PEG4)2, [177Lu]Lu-PSMA-617 exhibited detectable kidney uptake at 6 h, while, at the same time, DOTA-(2P-PEG4)2 had no obvious signal detected except for tumor, showing the advantage of DOTA-(2P-PEG4)2 in reducing radiation damage to the kidney. This evidence concerns the gene FOLH1 and neoplasm.