Specifically, we evaluated the production of IFN-γ and IL-2 in the whole blood after stimulation with SARS-CoV-2 peptide pools and the IgG directed against Spike glycoprotein in HD patients and Healthy Volunteers (HV) with (COVID-19 recovered individuals) or without (naïve individuals) previous infection of SARS-CoV-2. This evidence concerns the gene IL2 and Huntington disease.