In order to verify the regulatory role of FGFR2 in the development of liver fibrosis, two cell lines were established, i.e., the FGFR2 overexpressing HSC cell line (LX-2) and the liver cell line (Huh-7), and the sensitivity changes induced by TGF-β were compared between the two cell lines. The gene discussed is TGFB1; the disease is Hepatic fibrosis.