Although H2 has been reported to ameliorate lipid accumulation by regulating the miR-136/MEG3/Nrf2 pathway in NAFLD [58], it is unclear whether H2 could also regulate Nrf2 activity through the canonical Keap1-Nrf2-ARE pathway or other non-canonical pathways in metabolic diseases [85]. Here, NFE2L2 is linked to Other metabolic disease.