EGFR and cancer: The EGFR inhibition of EGFR-dependent cancer cells leads to cell cycle arrest in the G1/S phase before DNA synthesis [55] by up-regulation of p27KIP1 activity [56,57] and up-regulation of pro-apoptotic molecules, such as Bcl-2-interacting mediator of cell death (BIM) that activates the intrinsic mitochondrial apoptotic pathway and cell death [58,59].