EGFR and adenocarcinoma: The preliminary results of the LUX-Lung 7 clinical trial revealed an increased PFS (47% vs. 41%), higher ORR (70% vs. 54%), and time to treatment failure (TTF) in the afatinib treatment group compared to gefitinib for patients with adenocarcinoma and activating EGFR mutations with minimal OS differences (27.9 vs. 25 months) [150,151].