Modulation of Nrf2 associated with other signaling pathways has been reported as the molecular mechanism of protection against several diseases, including cardiac hypertrophy and fibrosis [90], diabetes, lipid metabolism, and insulin resistance [91,92], hepatotoxicity [93], inflammation [88], lung toxicity [94], and neuronal and renal damage [95,96,97]. This evidence concerns the gene NFE2L2 and cardiac hypertrophy.