TNF and gastroenteritis: Oral administration of 30 mg/Kg of umbelliferone in rats with acetic acid-induced intestinal inflammation improved the macroscopic and microscopic damage, reduced colon TNF-α, IL-6, MPO, and downregulated TLR4, NF-κB, and iNOS inflammatory factors, via upregulation of PPARγ and sirtuin 1 signaling pathways [128].