NFKB1 and leukemia: The effects of imperatorin at concentrations of 6.25, 12.5, and 25 μM were also evaluated on the human intestinal epithelial HCT116, LS174T, human leukemia THP-1, and HEK293T cell lines as an attempt to elucidate the main actions of imperatorin, which produced a range of effects, mainly acting as an agonist of pregnane X receptor and inhibiting the NF-κB-mediated TNF-α, IL-1β, and IL-6 pro-inflammatory cytokines production [145].