Among the coumarin derivatives here revised and displaying Nrf2/ARE signaling pathway activation to reduce oxidative stress and simultaneously promote intestinal anti-inflammatory activity, simple coumarins such as esculetin and its derivative 4-methylesculetin, daphnetin, and osthole, and the furanocoumarin imperatorin are attractive compounds for further backbone derivatization and screening as novel therapeutic agents potentially useful to control and prevent NCDs, particularly inflammatory bowel diseases. Here, NFE2L2 is linked to inflammatory bowel disease.