NFE2L2 and cardiac hypertrophy: Protective antioxidant properties of daphnetin upregulating the Nrf2/HO-1 pathway with simultaneous inhibition of transforming growth factor β1 (TGF-β1)/Smad2/3 signaling axis was demonstrated in rat cardiomyoblast H9c2 cells and transverse aortic constriction model in C57BL/6 mice, alleviating cardiac hypertrophy and fibrosis [90].