Nrf2 signaling pathway or Keap1-Nrf2-ARE (Kelch-like ECH-Associated protein 1-nuclear factor erythroid 2-related factor 2-antioxidant response element) system has been reported as the master defense mechanism against oxidative stress, which after activation by different products, is useful to control, prevent, and relieve several symptoms of NCDs, including hypertension and cardiovascular diseases, cancer, diabetes, obesity, neurodegenerative and aging diseases, and IBD [46,47,48,49,50,51,52,53]. This evidence concerns the gene NFE2L2 and obesity due to melanocortin 4 receptor deficiency.