NFE2L2 and inflammatory bowel disease: Given these facts, this review underpins the important recent advances in the study of coumarin derivatives as modulators of the Nrf2 signaling pathway and their use as promising lead compounds for the development of new drugs useful to control or treat NCDs with an emphasis on IBD, after briefly introducing Nrf2 signaling pathway to control oxidative stress and inflammatory processes and its particular importance for the control, prevention, and treatment of intestinal inflammatory processes.