In BALB/c mice asthma model using ovalbumin, imperatorin at 15, 30, and 60 mg/Kg regulated several signaling pathways, increasing the nuclear Nrf2 and HO-1 levels with a simultaneous reduction in cytosol Nrf2 and NF-κB, AKT, Erk, p-38 and JNK levels [144]. Here, NFE2L2 is linked to asthma.