OLR1 and atherosclerosis: Moreover, TMAO plays a critical role in the accumulation of ox-LDL in macrophages through upregulation of multiple scavenger receptors, CD36, lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), and class A1 scavenger receptors (SR-A1) [77], that contribute to the formation of atherosclerosis by enhancing cholesterol uptake with lipoprotein modifications [11].