This aim was based on previous studies which demonstrated the effectiveness of sarpogrelate, a selective 5-HT2A receptor antagonist, against ischemic cellular damage/ infarction size in rabbit hearts and MI in rats [10,16,17]; the isolated rat heart was protected against ischemia in terms of cardiac function by ketanserin and cinanserin’s inhibition of 5-HT2 receptors [18], concluding that inhibition of the 5-HT system by FLP may have cardioprotective effect in ISO-induced MI. Here, HTR2A is linked to ischemia.