It was previously reported the effectiveness of sarpogrelate, a selective 5-HT2A receptor antagonist, against ischemic cellular damage/ infarction size in rabbit hearts and MI in rats [10,16,17] and blockade of 5-HT2 receptors by ketanserin and cinanserin resulted in the protection of the isolated rat heart against ischemia in terms of cardiac function [18]. This evidence concerns the gene HTR2A and ischemia.