In addition, in vivo results showed that CUR/CDB-SLNs increased levels of CB1 and CB1-mRNA, p-MEK1, and p-ERK1/2 protein expressions in the striatal and hippocampus region, thus exhibiting a neuroprotective effect, and can be used as a potential strategy for treating major depression [85]. Here, CNR1 is linked to major depressive disorder.