Fucoxanthin can also reverse FFA-induced NAFLD by upregulating the nuclear factor erythroid-2-related factor 2 (Nrf2) and adenosine monophosphate-activated protein kinase (AMPK) signaling pathways and inhibiting the expression of protein involved in the Toll-like receptor 4 (TLR4) signaling pathway. The gene discussed is NFE2L2; the disease is metabolic dysfunction-associated steatotic liver disease.