Specifically, we aimed (1) to determine serum concentrations of IL-1β, Il-6 and TNF-α, considering differences according to disease activity and C reactive protein (CRP) levels, (2) to evaluate the prevalence of malnutrition risk using the CONUT score in patients with CD and its relationship with different indicators of nutritional status and inflammatory biomarkers; and eventually, (3) to identify potential predictors of malnutrition risk in patients with CD. The gene discussed is TNF; the disease is malnutrition.