Finally, 3991 subjects were included in the final cohort as the analytic samples after excluding 356 subjects with missing data on AST or ALT, 136 subjects with excessive alcohol consumption, 71 patients with positive serological markers for hepatitis B or C virus, 93 patients diagnosed with hepatitis B or C, 463 patients having a history of cancer, and 9 subjects having ESRD. This evidence concerns the gene GPT and cancer.