Due to its versatile roles in endothelial function [4], its involvement in activating the cortisol–adrenocorticotrophic hormone (ACTH) stress axis, its promotion of aldosterone [5] production as well as its multifactorial influence on energy homeostasis [2,6,7], insulin resistance [2,8] and cardiac function [9], VEGF-A is involved in various reciprocal relationships influencing cardiovascular and cardiometabolic risk factors such as glucose sensitivity, lipidemic profile, obesity and blood pressure. This evidence concerns the gene VEGFA and obesity due to melanocortin 4 receptor deficiency.