The limitations of the study are summarized as follows: (i) the limited but substantial number of participants compared to larger cohorts examining VEGF-A-related variants; (ii) the overall health status of the population used, which might not have promoted the identification of distinct associations with cardiometabolic risk factors, as for example in the case of patients with obesity or disrupted glucose metabolism and; (iii) the restricted variance of the populations’ habits explained by the previously extracted dietary patterns (46.69%) [19]. The gene discussed is VEGFA; the disease is obesity due to melanocortin 4 receptor deficiency.