Due to its versatile roles in endothelial function [4], its involvement in activating the cortisol–adrenocorticotrophic hormone (ACTH) stress axis, its promotion of aldosterone [5] production as well as its multifactorial influence on energy homeostasis [2,6,7], insulin resistance [2,8] and cardiac function [9], VEGF-A is involved in various reciprocal relationships influencing cardiovascular and cardiometabolic risk factors such as glucose sensitivity, lipidemic profile, obesity and blood pressure. The gene discussed is VEGFA; the disease is obesity disorder.