Therefore, we would suggest that the primary pathogenetic defects in PCOS could be an intrinsic altered androgen synthesis within the ovary, eventually complicated by other systemic factors (e.g., insulin resistance, deregulation of the hypothalamic–hypophysis axis, and obesity), with subsequent reduced FSH sensitivity, aromatase levels, and estradiol bioavailability [94]. This evidence concerns the gene CYP19A1 and polycystic ovary syndrome.