By suppressing the activities of Sirtuin 1 (SIRT1) and DNMTs, resveratrol and pterostilbene can synergistically inhibit cell viability, induce apoptosis, and arrest the cell cycle in triple-negative breast cancer cells, inhibiting telomerase activity and histone H2AX expression [3,5]. The gene discussed is SIRT1; the disease is triple-negative breast carcinoma.