Compared with the CDDP group, CDDP combined with A. muciniphila reduced tumor growth and volume;Compared with the CDDP group, CDDP combining with A. muciniphila, downregulated the levels of ki-67, p53, Fas ligand proteins, and upregulated Fas proteins, increased the levels of proinflammatory cytokines, and reduced the number of Treg lymphocytes in mouse peripheral blood and spleen. Here, FAS is linked to neoplasm.