The expression of matrix metalloproteinases (MMPs) and the imbalance of the phosphoryladylinositol 3-kinase (PI3K)/AKT/major target of rapamycin (mTOR) signaling pathway may both have an impact on the development of chronic diseases such as CVD, type 2 diabetes (T2D), and cancer [4,5]. The gene discussed is AKT1; the disease is type 2 diabetes mellitus.