In terms of clinical presentation, children with elevated total IgE (n = 40) at the diagnosis of Crohn’s disease more often presented with rectal bleeding (42.5 vs. 24.3%; chi2 = 4.1, p = 0.04; OR = 2.29 [1.01–5.17], p = 0.04; φ = 0.19), weight loss prior to diagnosis (62.5 vs. 42%; chi2 = 4.32, p = 0.037; OR = 2.27 [1.04–4.97], p = 0.04; φ = 0.19) and perianal disease (27.5 vs. 12.8%; chi2 = 3.9, p = 0.048; OR = 2.58 [0.99–6.74], p = 0.053; φ = 0.18). Here, IGHE is linked to Crohn disease.