In the 1980s and 1990s, the mechanisms of IBD were explored, including the presence of mast cells and IgE in the patient’s bowel wall [4,5], histamine secretion [6], the role of eosinophilia and IgE as an inflammatory mediator in IBD aetiology [7,8]. The gene discussed is IGHE; the disease is Increased total eosinophil count.