The promotion of musculoskeletal resistance to insulin is due to the presence of LPS, a marker of endotoxemia, which, through activation of the Toll like receptor-4 (TLR-4) pathways, leads to the final expression of proinflammatory cytokines such as TNF-α, interleukin-1 (IL-1), interleukin-2 (IL-2), and IL-6 [125,126]. The gene discussed is TLR4; the disease is serum lipopolysaccharide activity.