NFKB1 and Stroke: In OGD/R-treated microglial cells, which are often used to evaluate stroke and the consequent inflammatory injury, SI could inhibit proinflammatory cytokines and enzymes, attenuate the nuclear translocation of the NF-κB pathway in BV-2 microglia, and restrain the TLR4/NF-κB pathway or upregulate extracellular heat shock protein 70.