MAPK8 and chronic kidney disease: Our results showed that JNK, ERK1/2 and p38 kinases of the MAPKs signaling pathway were activated by inflammatory stimulation in the kidneys of 5/6Nx model rats, and SAA significantly inhibited the phosphorylation of related proteins in the kidneys of 5/6Nx rats, suggesting that SAA improves CKD through the MAPKs signaling pathway.