INS and diabetes mellitus: Currently, diabetes is managed by modification of lifestyle, exercise, diet and long-term use of hypoglycemics or insulin therapy [8]; however, owing to serious side effects of these synthetic drugs (gastrointestinal side effects by metformin and alpha-glucosidase inhibitors, significant hypoglycemia/weight gain by sulfonylureas, frequent dosing, expense and hypoglycemia by meglitinide); there is still a challenge to control diabetes [9].