We found that when colon cancer cells were treated with ES, cell viability inhibition (by MTT assay), the expression of c-Myc (by Western blotting, serum stimulation, IF, TUNEL assay), apoptotic proteins, oncogene inhibition (by Western blotting), and c-Myc stability reduction (by CHX) were apparent. The gene discussed is MYC; the disease is malignant colon neoplasm.