SREBF1 and hepatocellular carcinoma: Sharma et al. showed that trigonelline (50 μmol/L) reduced the expression of peroxisome proliferator-activated receptor-γ and sterol regulatory element-binding protein-1 in palmitic acid-induced fatty liver disease model human hepatoma (HepG2) cells, suggesting that trigonelline protects against the development of hepatocellular carcinoma by decreasing fatty-acid-mediated lipotoxicity [134].