Captopril, Saquinavir, Zanamivir, Boceprevir, Nolatrexed, Rupintrivir, Aliskiren, Dorzolamide, and Oseltamivir are the drugs that were developed using CADD initially, and they have shown promising results against heart failure, human immunodeficiency virus (HIV), swine flu, hepatitis C virus (HCV), liver cancer, human rhinovirus (HRV), human renin, ocular hypertension, and influenza in vitro, with some of them being in clinical phase 3 trials [47]. This evidence concerns the gene REN and heart failure.