However, a study by Kanayama et al. [64] proved that B7-H3 stimulates ARMS cell migration by regulating the expression of C-X-C chemokine receptor type 4 (CXCR4), and it was previously proved that this metastasis-associated molecule can activate different downstream signaling pathways such as JAK2/STAT3, PI3K/Akt, ERK, and NF-Κb in various cancers [101,102,103,104]. Here, CXCR4 is linked to cancer.