Although the abundant expression of B7-H3 in PSTs was observed by recent studies and shown to be associated with tumor aggressiveness and worse prognosis [4,11,12,64], the potential relationship between JAK2/STAT3, PI3K/Akt/mTOR, and Ras/Raf/MEK and B7-H3 in PSTs has still not been examined and further research is needed. This evidence concerns the gene JAK2 and neoplasm.