Furthermore, by modulating intracellular signal transduction pathways, such as Janus kinase/signal transducer and activator of transcription (JAK/STAT), phosphatidylinositol 3-kinase/protein kinase B (also known as Akt)/mammalian target of rapamycin (PI3K/Akt/mTOR), extracellular signal-regulated kinase (ERK), and nuclear factor-Κb (NF-Κb), B7-H3 may influence cancer cell metabolism, and promote invasion, metastasis, and resistance to anticancer therapy [9,37,38,39,40,41]. This evidence concerns the gene CD276 and cancer.