Compounds were tested for their ability to restore the Cl− conductance of Best1 mutants (p.L234V associated with BVMD and p.M325T associated with ARB) at 100-fold lower concentrations (25 μM) than 4PBA to identify more effective drugs for the treatment of the bestrophinopathies. Here, BEST1 is linked to Best vitelliform macular dystrophy.