In a study dealing with cytokine profiling [59] in different COVID-19 variants (ancestral Wuhan strain, Alpha, Delta, and Omicron), the authors showed that out of nearly 30 cytokines, only four showed stable elevation independently of the variant (IL-6, IL-10, IL-18, and IL-27), proposing them as ‘constant’ markers for COVID-19 infection. This evidence concerns the gene IL18 and COVID-19.