In conclusion, the present study demonstrated that Gochujang ameliorates hepatic inflammation by decreasing fat accumulation, dyslipidemia in serum and liver, production of pro-inflammatory parameters, and phosphorylation of the JNK/IκB/NF-κB pathway, but also by reshaping gut microbial composition in HD-induced obese mice. The gene discussed is NFKB1; the disease is metabolic syndrome.