Since obesity is usually accompanied by abnormal glucose metabolism, this experiment found that the GSP-treated group significantly reduced the blood glucose level in the serum of obese rats (p < 0.05) as well as increased the insulin level compared with the high-fat material control group, indicating that GSP has the effect of ameliorating hyperglycemia in obese rats. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.