These included reduced activation of renin angiotensin signaling, a critical long term regulator of systemic blood resistance and hypertension [42], p21 activated kinases (PAK) signaling involved in vascular integrity and arrhythmias [43], and IL-13 signaling, which is essential in repair and structural homeostasis of the heart [44,45,46]. This evidence concerns the gene IL13 and Hypertension.