The genetic features of IDH–wild-type glioblastoma include mutation in the telomerase reverse transcriptase (TERT) promoter; amplification of epidermal growth factor receptor (EGFR); loss of heterozygosity for 10q; deletion and point mutation of phosphatase and tensin homolog (PTEN); methylation of the MGMT promoter; a mutation in BRAF V600E. The gene discussed is IDH2; the disease is glioblastoma.