EGCG can actively interact with the E3-TRAF6 ubiquitin ligases Gln54, Gly55, Asp57 ILe72, Cys73, and Lys96; diminish the interconnection between TRAF6 and UBC13 (E2); hinder the signaling pathway of p65 and p50; and inactivate the NF-kB signaling pathway, thereby inhibiting melanoma’s cell growth, migration, and invasion [129]. This evidence concerns the gene TRAF6 and melanoma.