In a study from Bouchareychas and colleagues, when exosomes isolated from cultured mouse bone marrow-derived macrophages (BMDMs) that had been polarized to an anti-inflammatory M2 phenotype were injected into atherosclerosis-prone Western diet-fed ApoE−/− mice, necrotic lesion areas of atheroma were significantly reduced [68]. This evidence concerns the gene APOE and atherosclerosis.