What is more, Osali et al. showed that a diet rich in antioxidants (curcumin supplementation) together with training improved stress oxidative indices (increase in total antioxidant capacity and decrease in MDA) and inflammation markers (significant decreases in serum concentration of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6) and hs-CRP and increases in serum concentrations of brain-derived neurotrophic factor (BDNF) and interleukin 10 (IL-10)) in elderly women with metabolic syndrome [73]. This evidence concerns the gene TNF and metabolic syndrome.