FADS2 and acute myeloid leukemia: Levels of these and other HUFAs within the ω3 and ω6 desaturation pathways are shown in Figure 1C. Significantly increased linoleic acid (18:2, p < 0.01), dihomo-γ-linoleic acid (20:3, p < 0.01), and docosapentaenoic acid (22:5, p < 0.001), as well as those previously mentioned, suggest increased activity of both FADS1 and FADS2 in relapsed AML.