TP53 and cancer: In addition to phospholipid metabolism being implicated in the regulation of AML growth and stemness [33], PCs are of particular interest: increased levels of cell-membranous PCs containing PUFAs induced p53 phosphorylation through ataxia telangiectasia (ATR) activation [34], implying that PUFAs, including HUFAs, may play important roles in the signaling pathways relevant to cancer metabolism.