Consistent with our hypothesis of a role for FADS1 and 2 in LSC metabolic reprogramming, FADS1 and FADS2 expression overlapped with expression patterns of LSC-defining genetic markers (Figure 4B), suggesting FADS1 and FADS2 are overexpressed in self-renewing AML cells and are essential to LSC survival and pathogenesis. The gene discussed is FADS2; the disease is acute myeloid leukemia.