However, in 2012, Xekouki et al. described a patient with an acromegaly and concomitant presence of paragangliomas (PGLs) and pheochromocytomas (PHEOs) carrying a germline SDHD mutation while he exhibited loss of heterozygosity at the SDHD locus in the pituitary tumor, and increased transcription hypoxia-inducible factor α(HIF-1α) levels similar to the PHEO/PGLs [260]. This evidence concerns the gene HIF1A and pituitary tumor.