PIK3CG and neoplasm: Furthermore, the upregulation of several miRNAs (miR-17-5p, miR-20a, miR-106b, miR-21, miR200c, and miR-128) in pituitary tumors may inhibit the tumor suppressor signaling pathway PIK3/AKT, including PTEN, enabling a more aggressive behavior of these tumors [302,308].