CD4 and bacterial infectious disease with sepsis: Choudhury et al. [18] reported a patient with recurrent and persistent MSSA bacteremia and osteomyelitis, complicated by a spinal epidural abscess, bioprosthetic valve endocarditis, and aortic root abscess despite antibiotic treatment while having tested positive for SARS-CoV-2 infection, implying a COVID-19-induced immunocompromised state with functional exhaustion of CD4 and CD8 T-cells as the potential underlying mechanism for the persistence of such infections.