The bio-ADM levels were significantly higher in subjects with I/H-PAH (median (IQR): 15.50 (7.50–24.10) pg/mL) compared to those with ASD-PAH (median (IQR): 7.30 (4.10–13.50) pg/mL) and with ASD without PH (median (IQR): 5.15 (3.0–7.95) pg/mL), p = 0.024. Here, ADM is linked to atrial septal defect.