NPPB and hydrops fetalis: Dapagliflozin is safe and improves outcomes regardless of baseline NT-proBNP concentrations in HF with mildly reduced Ejection Fraction (HFmrEF) or HF with preserved Ejection Fraction (HFpEF), with the greatest absolute benefit likely seen in patients with higher NT-proBNP concentrations according to the findings of another large trial [57].