While vitiligo-like depigmentation has not been reported as a phenotypic feature of acatalasemia or hypocatalasemia, reports of low epidermal catalase activity in both lesioned and non-lesioned skin of patients with vitiligo with concomitant increases in epidermal H2O2 levels have suggested a possible role of catalase in vitiligo susceptibility. The gene discussed is CAT; the disease is acatalasia.