Recently, the Boston group reported that the absence of direct glycoprotein-specific platelet autoantibodies in their 61 assays was highly sensitive and specific (87% and 91%, respectively) for clinical ITP remission on TPO-RA treatment (a negative test had a positive likelihood ratio of 9.5 for remission) [40,41,42]. Here, TPO is linked to autoimmune thrombocytopenic purpura.