In particular, mutations in the B-Raf Proto-Oncogene, Serine/Threonine Kinase (BRAF) gene or Neuroblastoma RAS Viral Oncogene Homolog (NRAS) gene have been detected in most CM cases, with a frequency of 50–70% and 15–30%, respectively [1]. This evidence concerns the gene NRAS and cutaneous mastocytosis.