SERPINB5 and cancer: The genetic study showed that the Maspin gene is associated with the human chromosome 18q21.3-q23 (in the same region as the plasminogen-2 activator inhibitor gene (PAI-2), the DCC (colorectal cancer suppressor) tumor suppressor gene and the BCL-2 gene), whose cDNA consists of 2584 nucleotides and encodes a 42 kDa polypeptide [9,10,11,12].