Tumor cells can decrease T-cell signaling by downregulating the activity of stimulatory receptors while increasing the activity of inhibitory immunoreceptors [2]; for example, they can reduce TCR-mediated stimulatory signaling by downregulating surface MHC-I levels [3], or they may tune up PD-1-mediated inhibitory signaling by increasing PD-L1 surface expression [4]. The gene discussed is CD274; the disease is neoplasm.