Most of the key genes involved in these metabolic pathways are regulated by the thyroid hormone receptor-β, the most abundant isoform in hepatocytes that mediates the effects of thyroid hormones on hepatic carbohydrate and lipid metabolism, and novel selective thyroid hormone receptor-β agonists have recently shown beneficial effects on metabolic alterations, including NAFLD [8,9]. The gene discussed is TG; the disease is metabolic dysfunction-associated steatotic liver disease.